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The dental caries, cariogenic microorganisms and levels of salivary immunoglobulin in subjects with down¡¯s syndrome

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¾ç±ÔÈ£ ( Yang Kyu-Ho ) - Àü³²´ëÇб³ Ä¡°ú´ëÇÐ ¼Ò¾ÆÄ¡°úÇб³½Ç
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°­¹Ì¼± ( Kang Mi-Sun ) - Àü³²´ëÇб³ Ä¡°ú´ëÇÐ BK21»ç¾÷´Ü
ÀÓȸ¼± ( Lim Hoi-Soon ) - Àü³²´ëÇб³ Ä¡ÀÇÇÐÀü¹®´ëÇпø Ä¡ÀÇÇבּ¸¼Ò
¿ÀÁ¾¼® ( Oh Jong-Suk ) - Àü³²´ëÇб³ ÀÇ°ú´ëÇÐ ¹Ì»ý¹°Çб³½Ç

Abstract

´Ù¿îÁõÈıº ȯÀÚÀÇ Ä¡¾Æ¿ì½ÄÁõ°ú ±¸°­³» ¿©·¯ ¿äÀεé°úÀÇ ¿¬°ü¼ºÀ» Æò°¡ÇÏ°íÀÚ 9-18¼¼ÀÇ ´Ù¿îÁõÈıº ȯÀÚ 25¸í°ú Á¤»óÀÎ 63¸íÀ» ´ë»óÀ¸·Î Ä¡¾Æ¿ì½Ä°æÇèÁö¼ö, Ä¡ÅÂÁö¼ö¸¦ Á¶»çÇÏ°í È¿¼Ò¸é¿ªºÐ¼®¹ýÀ» ÀÌ¿ëÇÏ¿© Ÿ¾×ÀÇ ¸é¿ªÇ×ü IgA¿Í ¹Âź½º ¿¬¼â»ó±¸±Õ-ƯÀÌ IgA ³óµµ¸¦ ÃøÁ¤ÇÏ°í, Dentocult Å°Æ®¸¦ ÀÌ¿ëÇÏ¿© ¹Âź½º ¿¬¼â»ó±¸±Õ°ú À¯»ê°£±ÕÀÇ ¼ö, Ÿ¾×ÀÇ ¿ÏÃæ´ÉÀ» ÃøÁ¤ÇÏ¿© µÎ ±ºÀÇ °¢ °ªµéÀ» µ¶¸³ t-test¿Í Ä«ÀÌÁ¦°ö °ËÁ¤À» ½ÃÇàÇÏ¿´´Ù.

´Ù¿îÁõÈıº ȯÀÚ¿¡¼­ À¯Ä¡¿ì½Ä°æÇèÀº Á¤»óÀο¡ ºñÇØ À¯ÀÇÇÏ°Ô ³·¾ÒÀ¸³ª(p£¼0.001), ¿µ±¸Ä¡¿ì½Ä°æÇèÀº À¯ÀÇÇÑ Â÷À̸¦ º¸ÀÌÁö ¾Ê¾Ò´Ù. Ä¡ÅÂÁö¼ö¿Í Ÿ¾×ÀÇ IgAÀÇ ³óµµ´Â µÎ ±º °£¿¡ Â÷À̸¦ º¸ÀÌÁö ¾Ê¾ÒÀ¸¸ç, ¹Âź½º ¿¬¼â»ó±¸±Õ ƯÀÌ-IgA ³óµµ¿Í Ÿ¾× ¿ÏÃæ´ÉÀº ´Ù¿îÁõÈıºÈ¯ÀÚ¿¡¼­ ³·¾Ò´Ù(p£¼0.05), ¹Âź½º ¿¬¼â»ó±¸±Õ ¼ö¿Í À¯»ê°£±Õ ¼ö´Â µÎ ±º°£¿¡ À¯ÀÇÇÑ Â÷ÀÌ´Â ¾ø¾ú´Ù. 9-11¼¼ ±º¿¡¼­ ¹Âź½º ¿¬¼â»ó±¸±ÕÀÇ ¼ö´Â ´Ù¿îÁõÈıº ȯÀÚ¿¡¼­ Á¤»óÀκ¸´Ù ³·¾ÒÀ¸¸ç(p£¼0.001), ¹Âź½º ¿¬¼â»ó±¸±Õ ƯÀÌ-IgA´Â ´Ù¿îÁõÈıº ȯÀÚ¿¡¼­ À¯ÀÇÇÏ°Ô ³·¾Ò´Ù(p£¼0.05), À¯Ä¡ÀÇ Ä¡¾Æ¿ì½Ä°æÇèÄ¡¸éÁö¼ö´Â ¿ÏÃæ´É, ¹Âź½º ¿¬¼â»ó±¸±ÕÀÇ ¼ö¿Í À¯ÀÇÇÑ »ó°ü°ü°è¸¦ º¸¿´´Ù.

This study investigated the relationship between dental caries and various oral factors in subjects with Down¡¯ s syndrome. We compared 25 subjects with Down¡¯s syndrome with 63 healthy control. The dental caries index and plaque index were examined, and the total salivary immunoglobulin A and S. mutans specific salivary immunoglobulin A concentration were measured using ELISA. The S. mutans counts, Lactobacillus counts and buffer capacity were measured with Dentocult test medium.

The decayed and filled surface index of deciduous teeth in subjects with Down¡¯ s syndrome was lower than in controls(p<0.001). The plaque index and total salivary immunoglobulin A concentration showed no difference, S. mutans specific salivary immunoglobulin A concentration and buffer capacity in subjects with Down¡¯ s syndrome were lower than in controls(p<0.001). There was no significant difference between two groups in the S. mutans counts and Lactobacillus counts. In 9-11 year age group, S. mutans counts in subjects with Down¡¯ s syndrome was lower than in controls(p(0.001) and S. mutans specific salivary immunoglobulin A concentration was lower(p(0.05). There was a high correlation among deciduous dental caries index and buffering capacity and S. mutans counts.

Å°¿öµå

´Ù¿îÁõÈıº; Ä¡¾Æ¿ì½ÄÁõ; ¹Âź½º ¿¬¼â»ó±¸±Õ; ¿ÏÃæ´É; Ÿ¾× ¸é¿ªÇ×ü; ¹Â½ºÅº ¿¬¼â»ó±¸±Õ-ƯÀÌ Ç×ü
down¡¯s syndrome; dental caries; sterptococcus mutans; buffer capacity; salivary immunoglobulin A; streptococcus mutans-specific salivary immunoglobulin A

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